PROCESS FOR PRODUCING OPTICALLY ACTIVE N-MONOALKYL-3­HYDROXY-3-ARYLPROPYLAMINE COMPOUND AND INTERMEDIATE

摘要

A process for producing an optically active N-monoalkyl­3-oxo-3-arylpropylamine compound represented by the formula (3): (wherein symbol * indicates an asymmetric carbon atom and R<1> represents optionally substituted C1-5 alkyl), characterized by asymmetrically reducing a (Z)-protected-N-monoalkyl-3-oxo­-3-arylpropenylamine compound represented by the formula (1): (wherein Ar represents optionally substituted aryl, etc.; R<1> is the same as defined above; and R<2> represents an amino-protecting group) with an asymmetric catalyst to give an optically active compound represented by the formula (2): (wherein symbol * is the same as defined above) and successively eliminating the protective group.