Modulating, e.g., preventing, inhibiting or treating thrombosis, comprising administering a P-selectin antagonist to subject with cardiovascular disorder such as atherosclerosis or hypertension

摘要

Methods and compositions for the modulation of thrombosis, in a subject, by administering a P-selectin antagonist are described. Further provided are methods for modulating leukocyte recruitment, cellular migration, leukocyte rolling velocity, intercellular adhesion, and cell adhesion to blood vessels in a subject by administering soluble P-selectin ligand or fragments thereof, an anti-P-selectin ligand antibody, or an anti-P-selectin antibody. Methods for identifying compounds capable of modulating thrombosis are also provided.