GLYOXALASE INHIBITORS

摘要

This invention relates to compounds of formula (I) which are glyoxalase I inhibitors, pharmaceutical salts or compositions comprising such compounds, and the use of such compositions and compounds to treat various conditions alleviated by the inhibition of glyoxalase I. Wherein X is N or CH. R<2> is H, CF3; or optionally substituted C5-6 aryl, C3-7 cycloalkyl, C5-7 heterocyclyl. R<3> is H; or optionally substituted C5-6 aryl, C3-7 cycloalkyl, C5-7 heterocyclyl. Alternatively R<2> and R<3> together form an optionally substituted C3-4 alkylene group wherein L<3> and L<4> are single bonds thus forming a C5-6 ring fused with the aromatic ring to which L<3> and L<4> are attached. L<3> and L<4> are independently selected from a single bond, optionally substituted C1-4 alkylene, -L<9>YN(OH)C(=O)L<10>- and -L<9>C(=O)N(OH)YL<10>-, wherein L<9> and L<10> are independently selected from optionally substituted C1-4 alkylene, C5-6 arylene, C1-4 alkylene-C5-6 arylene and a single bond, wherein Y is NH or a single bond.