| 发明名称 |
METHODS FOR TREATING CANCERS AND RESTENOSIS WITH P21 |
| 摘要 |
The p21 gene encodes a cyclin dependent kinase inhibitor which affects cell cycle progression, but the role of this gene product in altering tumor growth has not been established. The present inventors have now discovered that the growth of malignant cells in vivo is inhibited by expression of p21. Expression of p21 resulted in an accumulation of cells in G0/G1, alteration in morphology, and cell differentiation. |
| 申请公布号 |
EP0859639(A4) |
申请公布日期 |
2004.11.24 |
| 申请号 |
EP19960933082 |
申请日期 |
1996.09.26 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
NABEL, GARY, J.;YANG, ZHI-YONG;NABEL, ELIZABETH, G. |
| 分类号 |
C12N15/09;A01N43/04;A61K31/00;A61K31/70;A61K35/76;A61K38/00;A61K38/17;A61K48/00;A61P9/00;A61P35/00;C07K14/47;C12N7/00;C12N15/00;C12N15/63;C12N15/85;C12R1/645;(IPC1-7):A61K48/00 |
主分类号 |
C12N15/09 |
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