METHODS FOR TREATING PANCREATIC CANCER USING COMBINATION THERAPIES COMPRISING LIPOSOMAL IRINOTECAN

摘要

Provided are methods for treating pancreatic cancer in a patient by administering liposomal irinotecan (MM-398) alone or in combination with additional therapeutic agents. In one embodiment, the liposomal irinotecan (MM-398) is co-administered with 5-fluorouracil and leucovorin.

主权项

1. A method of treating pancreatic cancer in a human patient, the method comprising intravenously administering to the patient once every two weeks an antineoplastic therapy comprising:
a. a single administration of 80 mg/m2 of the antineoplastic agent irinotecan encapsulated in a liposome, in combination with b. a single administration of 200 mg/m2 of (l) form of leucovorin, and c. a single administration of 2400 mg/m2 of the antineoplastic agent 5-fluorouracil to treat the pancreatic cancer in the patient,wherein no other antineoplastic agent is administered to the patient during the two week administration period.