TASTE MASKED MICROCAPSULES AND PROCESSES FOR THEIR PREPARATION

摘要

The invention relates to compositions and methods for taste-masking bitter, unpleasant tasting medicaments. The invention further relates to taste-masked coated granules of a bitter pharmaceutical agent that can be reconstituted as a liquid suspension. The taste-masked pharmaceutical granule composition includes a core, a first coating layer and a second coating layer. The core includes one or more bitter tasting pharmaceutically active agents, one or more hydrocolloid materials, and, optionally, one or more flavoring agents. The first coating layer includes one or more hydrophobic materials and covers at least a portion of the core. The second coating layer includes one or more enteric film forming polymers and one or more waxy materials and covers at least a part of the first coating layer.