发明名称 |
ANTIBODY CATALYSIS OF ENANTIO- AND DIASTEREO-SELECTIVE ALDOL REACTIONS |
摘要 |
Nine efficient aldolase antibodies were generated using hapten 2. This hapten combines, in a single molecule, structural components employed for reactive immunization with structural components employed for forming a transition state analog of the aldol reaction. Characterization of two of these antibodies reveals that they are highly proficient (up to 1000-fold better than any other antibody catalyst) and enantioselective catalysts for aldol and retro-aldol reactions and exhibit enantio- and diastereo-selectivities opposite that of antibody 38C2. |
申请公布号 |
EP1228087(A4) |
申请公布日期 |
2004.11.03 |
申请号 |
EP20000968865 |
申请日期 |
2000.10.06 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
BARBAS, CARLOS, F.;LERNER, RICHARD, A.;ZHONG, GUOFU |
分类号 |
C07D277/24;C07D277/34;C07D277/36;C07D417/06;C07D493/04;C07K16/40;C12N9/00;C12P7/26;C12P17/16;C12P17/18;C12P21/08;C12P41/00 |
主分类号 |
C07D277/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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