ANTISENSE NUCLEIC ACIDS

摘要

Antisense oligonucleotides sequences that inhibit expression of anthrax toxin receptor (ATR) mRNA and human tumor endothelial marker 8 have been designed and constructed. The antisense oligonucleotides may be used to inhibit anthrax infection of host cells as well as for treating cancerous tumors. Introducing such antisense oligonucleotides into a cell decreases ATR expression and decreases tumor cell viability in vitro. Methods for discovering other oligonucleotides with the same activity are taught, as are uses of the antisense molecules for treatment of diseases.