摘要 |
The invention provides a PYY agonist derivative of the formula: (X)n - Z, wherein X is a radical 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenyl-methoxycarbonyl (FMS), Z is the residue of a PYY agonist linked to the radical X through an amino or hydroxyl group, and n is 1 to 3, or a pharmaceutically acceptable salt thereof, for reducing food intake and treatment of a disease, condition or disorder that can be alleviated by reduction of food intake such as obesity, hypertension, dyslipidemia, cardiovascular risk, eating disorder, insulin-resistance, or diabetes mellitus. |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD.;RUBINSTEIN, MENACHEM;SHECHTER, YORAM;FRIDKIN, MATITYAHU |
发明人 |
RUBINSTEIN, MENACHEM;SHECHTER, YORAM;FRIDKIN, MATITYAHU |