发明名称 |
PHARMACEUTICAL USE OF 1-AZABICYCLO[2.2.2]OCTANES AND A METHOD OF TESTING COMPOUNDS FOR THE ABILITY OF ACTIVATING INACTIVE WT P53 |
摘要 |
<p>The present invention relates to the use of 1-azabicyclo[2.2.2]octanes, capable of transferring wild type p53 from an inactive and non-functional conformation into an active conformation, for the preparation of a pharmaceutical compositions for use in treating medical compositions wherein wt p53 exists in an inactive state defined herein, especially malignant melanoma and conditions involving undesired angiogenesis. The inven-tion also relates to methods of in vivo and in vitro testing of compounds for the above-mentioned ability, wherein inactive wt p53 is monitored or detected.</p> |
申请公布号 |
WO2004084893(A1) |
申请公布日期 |
2004.10.07 |
申请号 |
WO2004SE00452 |
申请日期 |
2004.03.24 |
申请人 |
APREA AB;STROEMBLAD, STAFFAN;BAO, WENIJE;SELIVANOVA, GALINA;ISSAEVA, NATALIA |
发明人 |
STROEMBLAD, STAFFAN;BAO, WENIJE;SELIVANOVA, GALINA;ISSAEVA, NATALIA |
分类号 |
A61K31/4015;A61K31/439;A61K31/52;A61P35/00;G01N33/50;(IPC1-7):A61K31/439;A61K31/401 |
主分类号 |
A61K31/4015 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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