The present invention is directed to novel polypeptides and variants thereof of GLM-R polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided are methods for detecting agents that modulate the activity of GLM-R. Also provided are methods for diagnosing and for treating disorders characterized by the over or under abundance of monocytes or macrophages.
申请公布号
WO03072740(A3)
申请公布日期
2004.09.30
申请号
WO2003US05616
申请日期
2003.02.24
申请人
GENENTECH, INC.
发明人
DE SAUVAGE, FREDERIC, J.;GHILARDI, NICO, P.;GODDARD, AUDREY;GODOWSKI, PAUL, J.;GRIMALDI, CHRISTOPHER, J.;GURNEY, AUSTIN, L.;WOOD, WILLIAM, I.
