Indole derivatives having affinity for dopamine D4 receptor and their use for the treatment of psychiatric or neurologic disorders

摘要

Dopamine and serotonin receptor ligands of formula (I) are disclosed, wherein one of Y1 and Y2 is N, which is bound to Y4, Y3 is Z-CH2, CH2-Z or CH2CH2 and the further meanings of Y1, Y2, Y3, Y4, Z, W, n, m, X, R1-R9 and R10 are as described in the specification. The compounds of formula (I) are useful in the treatment of certain psychiatric and neurological disorders, i.e. schizophrenia, other psychoses, anxiety disorders, depression, migraine, cognitive disorders, ADHD and sleep improvement.