PROTECTION OF AMINE AND HYDROXYL GROUPS USING FLUOROACYLATION

摘要

The invention describes the novel use of trifluoroacylation to generate protecting groups for amine and hydroxyl groups in strong nitrolysing media. Trifluoroacyl compounds not only provide excellent protection from media such as nitric acid/oleum but in turn may be readily de-protected by alcholic solvents. In particular the invention describes how trifluoroacetylation may be used to selectively protect secondary amine groups and hydroxyl groups.