New crystalline paroxetine hydrochloride hemi:hydrate - used in treating depression

摘要

Crystalline paroxetine hydrochloride hemihydrate (Ia) is new: Cpds. of formulae (II) and (IV) are new: where X=H, 1-4C alkyl, alkoxy, trifluoroalkyl, OH, halogen, SMe or aralkoxy; R'=alkyl; R2=1-4C alkyl or alkynyl, or phenyl opt. substd. by 1-4C alkyl, alkylthio, alkoxy, halogen, NO2, acylamino, methylsulphonyl or methylenedioxy, or is tetrahydronaphthyl.