| 摘要 |
A biological device capable, upon impaction in a lung capillary of a patient suffering from cystic fibrosis, of treating the patient comprising or including: 1. one or more cells exhibiting substantially normal CFTR production; 2. one or more coatings of a suitable biocompatible material around the one or more cells; 3. one or more proteases associated with the one or more coatings; Wherein the size of the biological device is such that, upon introduction to the venous system of the patient the device will impact substantially in the region of a lung capillary of the patient. And wherein upon impaction, by disruption of the outer surface of the device or otherwise, the one or more proteases are able to act upon a wall of the lung capillary, thereby allowing access (directly or indirectly) of the one or more cells to the lung epithelia. The method of preparing the biological device is also discussed.
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