PEPTIDES AND DERIVATIVES THEREOF SHOWING CELL ATTACHMENT, SPREADING AND DETACHMENT ACTIVITY

摘要

The present invention relates to peptides and derivatives thereof showing cell attachment, spreading and detachment activity. Particularly, the present invention relates to the peptide NKDIL and EPDIM and derivatives thereof which promote the cell attachment activity through interaction with a alpha 3beta 1 integrin as a functional cell receptor and include aspartic acid and isoleucine essential for cell attachment and detachment activity. The peptides and derivatives thereof in the present invention can be used for developing a study of cell attachment activity mediated through various extracellular matrix protein containing beta ig-h3, wound healing, tissue regeneration and metastasis inhibition.