发明名称 |
METHODS AND APPARATUS FOR MAKING PARTICLES USING SPRAY DRYER AND IN-LINE JET MILL |
摘要 |
<p>Methods and apparatus are provided for making particles comprising: (a) spraying an emulsion, solution, or suspension, which comprises a solvent and a bulk material (e.g., a pharmaceutical agent), through an atomizer (14) and into a primary drying chamber (12), having a drying gas flowing therethrough, to form droplets comprising the solvent and bulk material dispersed in the drying gas; (b) evaporating, in the primary drying chamber (12), at least a portion of the solvent into the drying gas to solidify the droplets and form particles dispersed in drying gas; and (c) flowing the particles and at least a portion of the drying gas through a jet mill (24) to deagglomerate or grind the particles. By coupling spray drying with "in-line" jet milling, a single step process is created from two separate unit operations, and an additional collection step is advantageously eliminated. The one-step, in-line process has further advantages in time and cost of processing.</p> |
申请公布号 |
WO2004060547(A1) |
申请公布日期 |
2004.07.22 |
申请号 |
WO2003US37108 |
申请日期 |
2003.11.20 |
申请人 |
ACUSPHERE, INC. |
发明人 |
CHICKERING, DONALD, E., III;NARASIMHAN, SRIDHAR;ALTREUTER, DAVID;KOPESKY, PAUL;KEEGAN, MARK;STRAUB, JULIE, A.;BERNSTEIN, HOWARD |
分类号 |
A61K9/16;B01D1/18;B01J2/04;F26B3/12;F26B17/10;(IPC1-7):B01J2/04 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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