FLUORINE-SUBSTITUTED CATECHOL N-METHYL HYDRAZIDE DERIVATIVE

摘要

PURPOSE: Provided is a fluorine-substituted catechol N-methyl hydrazide derivative which has an inhibition effect to phosphodiesterase(PDE) IV or tumor necrosis factor(TNF), and a pharmaceutically acceptable composition comprising the same. CONSTITUTION: The fluorine-substituted catechol N-methyl hydrazide derivative is represented by formula 1. In the formula 1, R1 is (C3-C7)cycloalkyl, cyclopropylmethyl, indane or benzyl group, R2 is hydrogen or (C1-C5)alkyl group, Y is a direct bond or -C(=O)-, or -C(=O)O-, R3 is (C1-C7)alkyl selectively substituted with one or two of halogen, hydroxy, phenyl or amine compound or unsubstituted (C1-C7)alkyl, phenyl selectively substituted with one or two of nitro, nitrile, halogen, (C1-C3)alkyl or (C1-C3)alkoxy group or unsubstituted phenyl, wherein halogen is Cl, F, or Br.