PRP DETECTION METHOD USING AN ANCILLARY MACROCYCLIC LIGAND

摘要

The invention relates to a method of detecting pathogenic forms of the prion responsible for transmissible subacute spongiform encephalopathies. The inventive method is characterised in that an ancillary macrocyclic ligand (AML) which is free or bound to a support is added to a biological sample that may contain PrP, the resulting suspension is reacted with an anti-PrPantibody and the presence of PrP is detected.