ANTI-CANCER AGENTS

摘要

A pharmaceutical combination which comprises: (a) a compound of one of the formulae: formula (I) wherein each of R and R, which max be the same or different, represents hydrogen, fluorine or alkyl of 1 to 6 carbon atoms, X represents CR R, NR or O wherein R is hydrogen or alkyl of 1 to 6 carbon atoms, each of Y and Z, which may be the same or different, represents hydrogen, NR, OH or SH, or Y and Z together represents =O or =S, or formula (II) where R<1> to R<11> may independently be H, a branched or straight C1 to C6 alkyl chain, OH, O-alkyl having a branched or straight C1 to C6 alkyl chain optionally containing 1 or 2 N, O or S atoms, COOH, a branched or straight C1 to C6 alkyl ester (alkoxycarbonyl), a 4 to 7 membered heterocyclic ring optionally containing 1 or 2 N, S, O or P atoms or a 5 or 6 membered aromatic ring, optionally containing 1 or more N, O or S atoms, which can be fused to another ring, or a said alkyl chain substituted by a said aromatic ring, and formula (A) represents formula (B) or formula (C) or a pharmaceutically acceptable salt of a said compound; and (b) an anti-cancer alkylating agent. This combination is useful in the treatment of cancer.