TRIPTOLIDE DERIVATIVES AS IMMUNOMODULATOR AND ANTICANCER AGENTS

摘要

Compounds having the structure I are useful for inducing cell death (apoptosis) and in immuno suppression. In structure I, R<1> is H or R, R being selected from lower alkyl, alkenyl, alkynyl, and allenyl, or, R<1> together with R<2> = O (oxo); R<2> = OH, or, R<1> and R<2> together = O (oxo); CR<3>R<5> and CR<4>R<6> are selected from CH<2>, CHOH and CROH; at least one of R<1>, R<5> and R<6> is R; and at least one of CR<3>R<5> and CR<4>R<6> is CH<2>.