发明名称 |
2-AMINOPROPANE-1,3-DIOL COMPOUNDS, MEDICINAL USE THEREOF, AND INTERMEDIATES IN SYNTHESIZING THE SAME |
摘要 |
The present invention relates to a compound of the general formula <CHEM> wherein m is 0 to 9, and R<1a>, R<2a>, R<3a> and R<4a> are the same or different and each is a hydrogen or an acyl, with the proviso that m is not 4; a pharmaceutically acceptable acid addition salt thereof or a hydrate thereof; a pharmaceutical comprising this compound; and a pharmaceutical composition comprising this compound and a pharmaceutically acceptable carrier. The compound of the present invention shows superior immunosuppressive action with less toxicity and higher safety, and is useful as a drug for preventing or suppression of rejection of organs or bone marrow transplantation, or as a drug for prevention or treatment of various autoimmune diseases or allergic diseases. |
申请公布号 |
EP1002792(B1) |
申请公布日期 |
2004.07.14 |
申请号 |
EP19980911211 |
申请日期 |
1998.04.03 |
申请人 |
MITSUBISHI PHARMA CORPORATION |
发明人 |
ADACHI, KUNITOMO;AOKI, YOSHIYUKI;HANANO, TOKUSHI;TESHIMA, KOJI;HOSHINO, YUKIO;FUJITA, TETSURO |
分类号 |
A61K31/13;A61K31/135;A61P37/00;A61P37/06;C07C;C07C215/10;C07C215/34;C07C223/02;C07C225/08;C07C225/16;C07F7/18;(IPC1-7):C07C225/16 |
主分类号 |
A61K31/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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