USE OF NUCLEAR HORMONE RECEPTORS TO IDENTIFY MEIOSIS REGULATING COMPOUNDS

摘要

The present invention relates to the use of nuclear hormone receptors (NRs) to identify agonizes or antagonists of the NR/logan interaction. NRs are exemplified with liver-x-receptors. With either agonizes or antagonists, the metabolism and reactivity of cells which express NR are controlled, thereby providing a means to control meiosis in order to treat infertility or to achieve a novel principle of contraception. The invention further relates to a method for screening for legends to the NR, i. E. agonizes or antagonists of FF-MAS activity.