发明名称 |
METHODS FOR THE IDENTIFICATION, ASSESSMENT, AND TREATMENT OF PATIENTS WITH PROTEASOME INHIBITION THERAPY |
摘要 |
The present invention is directed to the identification of markers that can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to treatment. In particular, the present invention is directed to the use of certain combinations of markers, wherein the expression of the markers correlates with responsiveness or non-responsiveness to a therapeutic regimen comprising proteasome inhibition. Thus, by examining the expression levels of individual markers and those comprising a marker set, it is possible to determine whether a therapeutic agent, or combination of agents, will be most likely to reduce the growth rate of tumors in a clinical setting. |
申请公布号 |
AU2003298873(A1) |
申请公布日期 |
2004.06.30 |
申请号 |
AU20030298873 |
申请日期 |
2003.12.04 |
申请人 |
MILLENNIUM PHARMACEUTICALS, INC. |
发明人 |
GEORGE MULLIGAN;BARBARA, M. BRYANT;MICHAEL, P. MORRISSEY;ANDREW BOLT;ANDREW, I. DAMOKOSH |
分类号 |
A61K39/395;C07K14/47;C12Q1/68;G01N33/574 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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