摘要 |
Isolated human monoclonal antibodies which bind to and inhibit human CD20, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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申请人 |
GENMAB A/S;TEELING, JESSICA;RUULS, SIGRID;GLENNIE, MARTIN;VAN DE WINKEL, JAN, G., J.;PARREN, PAUL;PETERSEN, JORGEN;BAADSGAARD, OLE, D., M., SC.;HUANG, HAICHUN |
发明人 |
TEELING, JESSICA;RUULS, SIGRID;GLENNIE, MARTIN;VAN DE WINKEL, JAN, G., J.;PARREN, PAUL;PETERSEN, JORGEN;BAADSGAARD, OLE, D., M., SC.;HUANG, HAICHUN |