发明名称 |
COMPOSITION FOR TREATING CHLAMYDIA INFECTIONS AND METHOD FORIDENTIFYING SAME |
摘要 |
The invention relates to therapeutic modalities and pharmaceutical compositions for the treatment of Chlamydia-infection using cyclophilin polypeptides and its corresponding human cellular binding partner or partner s as a target for intervention. The present invention relates to the use of exogenous or engrafted sources of cyclophilins, anti-cyclophilin antibodies, cyclophilin decoys, soluble forms of cyclophilin-binding partners and small molecules which are supplied extracellularly, and act presumably by interrupting the binding of cyclophilin A with its cellular binding partner( s) or receptor(s), as a treatment for Chlamydia-infection. The present inventio n further relates to screening assays for the identification of compounds that inhibit the interaction of cyclophilin and its Chlamydia binding partners.</ SDOAB>
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申请公布号 |
CA2506738(A1) |
申请公布日期 |
2004.06.10 |
申请号 |
CA20032506738 |
申请日期 |
2003.11.24 |
申请人 |
WYETH |
发明人 |
SANKARAN, BANUMATHI;METCALF, BENJAMIN J.;WOOTERS, JOSEPH L. |
分类号 |
A61K38/12;C12Q1/18;C12Q1/48;G01N33/53;G01N33/569;(IPC1-7):G01N33/53 |
主分类号 |
A61K38/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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