| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for purifying new peroral antibiotic Cefixime having highβ-lactamase stability. SOLUTION: The method comprises reacting e.g. 7-amino-3-vinyl-3-cephem-4-carboxylic acid with e.g. 2-(aminothiazol-4-yl)-2-(tert-butoxycarbonylmethoxyimino)acetic acid-S-mercaptobenzo-thiazolyl ester to obtain e.g. 7-[2-(aminothiazol-4-yl)-2-(carboxymetoxyimino)acetamide]-3-vinyl-3-cephem-4-carboxylic acid of formula I and making a crystalline salt with amine by using the acid. COPYRIGHT: (C)2004,JPO
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