发明名称 |
VERFAHREN ZUR HERSTELLUNG EINES 18 F-MARKIERTEN GLYKOSYLIERUNGSREAGENZ SOWIE 18 F- GLYKOSYLIERUNGSREAGENZ UND DESSEN VERWENDUNG |
摘要 |
<p>An <18>F-labelled glycosylating agent is prepared by: (a) reaction of a hexose (I) with phosphoric acid (H3PO4); (b) hydrolysis of the product with a base; and (c) reaction of the product with uridine triphosphate (UTP) in the presence of pyrophosphorylase and Mg<2+>. Preparation of an <18>F-labelled glycosylating agent comprises: (a) reaction of a hexose of formula (I) with phosphoric acid (H3PO4); (b) hydrolysis of the product with a base; and (c) reaction of the product with uridine triphosphate (UTP) in the presence of a phosphorylase and Mg<2+>. one group R = <18>F in position 2, 3, 4 or 6 of the hexose ring, and the other three = a protecting group which is linked to the hexose ring via an oxygen atom An Independent claim is included for a glycosylating reagent of formula (II): one group R' = <18>F in position 2, 3, 4 or 6 of the hexose ring, and the other three R' groups = OH; OUDP = a uridine diphosphate group</p> |
申请公布号 |
AT265235(T) |
申请公布日期 |
2004.05.15 |
申请号 |
AT20000103937T |
申请日期 |
2000.02.25 |
申请人 |
FORSCHUNGSZENTRUM JUELICH GMBH |
发明人 |
PRANTE, OLAF;HAMACHER, KURT, DR.;COENEN, HEINZ H., PROF. |
分类号 |
A61K51/04;C07H3/02;(IPC1-7):A61K51/04 |
主分类号 |
A61K51/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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