QUINOLINE DERIVATIVE AND QUINAZOLINE DERIVATIVE INHIBITING SELF-PHOSPHORYLATION OF HEPATOCYTUS PROLIFERATOR RECEPTOR, AND MEDICINAL COMPOSITION CONTAINING THE SAME

摘要

4-Phenoxy or phenylthio-quinoline and quinazoline derivatives (I) are new. 4-Phenoxy or phenylthio-quinoline and quinazoline derivatives of formula (I) and their salts and solvates are new. [Image] X : CH or N; Z, L : O or S; M : C(R 1 0)R 1 1 or NR 1 2; R 1 0, R 1 1H, 1-4C alkyl or 1-4C alkoxy; R 1 2H or 1-4C alkyl; R 1-R 3H, OH, halo, NO 2, Q or A, 2-6C alkenyl, 2-6C alkynyl or O-A all optionally substituted by OH, halo, O-A, COO-A, Q or Cyc (optionally substituted by A, 1-6C hydroxyalkyl or O-A); Q : amino (optionally substituted by A, 1-6C hydroxyalkyl or O-A); A : 1-6C alkyl; Cyc : optionally unsaturated 3-8 membered carbocyclyl or heterocyclyl; R 5-R 8H, halo, A or O-A; R 9A (optionally substituted by R 1 4, T-R 1 5 or N(R 1 6)R 1 7), N(R 1 8)R 1 9 or Cyc 1; T : O, S or NH; R 1 4Cyc 1; R 1 5-R 1 7A or Cyc 1; Cyc 1Cyc (optionally substituted by A, O-A, halo, NO 2, CF 3, COO-A, CN, 1-6C cyanoalkyl, S-A, phenoxy, acetyl or 5 or 6 membered optionally unsaturated heterocyclyl or 2 alkyl substituents together form alkylene; R 1 8, R 1 9H, A (optionally substituted by O-A, S-A or Cyc 2) or Cyc 2; Cyc 2Cyc 1 or Cyc 1 fused to another Cyc 1 group; and provided that: (a) when X is CH, then Z and L is O, and M is NH, and R 1, R 4-R 8 is H; and (b) R 2 and R 3 is OMe then R 9 is not phenyl, OEt or pyridin-2-yl. ACTIVITY : Cytostatic. In tests on nude mice implanted with MKN45 cells a compound of formula (Ia) at 30 mg/kg b.i.d orally for 5 days reduced tumor growth by 81%. MECHANISM OF ACTION : HGF-Inhibitor.