| 摘要 |
FIELD: technological processes; medicine. ^ SUBSTANCE: variant contains one or several modifications in the area, which is limited by amino acids 16-153 of sphingosinekinase of wild type. Invention also stipulates the molecule of nucleonic acid that contains sequence that codes this sphingosinekinase. According to the present invention, sphingosinekinase may be used for prophylactics or treatment of decease of mammals, which is characterised with abnormal, unwanted or other improper activity of cells. ^ EFFECT: preparation of new sphingosinekinase with reduced catalytic activity. ^ 24 cl, 15 dwg, 4 tbl, 5 ex |
