发明名称 |
Pneumolysin mutants and pneumococcal vaccines made therefrom |
摘要 |
Mutants of pneumolysin that are non-toxic by reason of amino acid substitutions have been constructed. These mutants elicit an immune response in animals that is reactive to wild-type pneumolysin. The invention also encompasses vaccines for humans based on these mutants, including vaccines comprising conjugates with pneumococcal capsular polysaccharides.
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申请公布号 |
US6716432(B1) |
申请公布日期 |
2004.04.06 |
申请号 |
US19950378213 |
申请日期 |
1995.01.25 |
申请人 |
PATON JAMES CLELAND;HANSMAN DAVID JOHN;BOULNOIS GRAHAM JOHN;ANDREW PETER WILLIAM;MITCHELL TIMOTHY JOHN;WALKER JOHN ARTHUR |
发明人 |
PATON JAMES CLELAND;HANSMAN DAVID JOHN;BOULNOIS GRAHAM JOHN;ANDREW PETER WILLIAM;MITCHELL TIMOTHY JOHN;WALKER JOHN ARTHUR |
分类号 |
A61K39/00;C07K14/315;(IPC1-7):A61K39/00;A61K39/38;A61K39/02;A61K39/09 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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