| 摘要 |
PROBLEM TO BE SOLVED: To provide a new pathogenic prion production inhibitor. SOLUTION: The pathogenic prion production inhibitor comprises a compound having a nitrogen-containing heterocyclic group such as a quinoline ring, a quiniclidine ring or a pyridine ring or a nitrogen-containing side chain such as an aliphatic amino group, an aromatic amine or hydrazine on 2-position or 4-position of a nitrogen-containing heterocyclic ring such as a quinoline ring or naphthylidine ring. The inhibitor can be used for treatment of prion diseases such as shuman Creutzfeldt-Jakob disease, Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia, animal scrapie and bovine spongiform encephalopathy (mad cow disease). COPYRIGHT: (C)2004,JPO
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