TRANSGENIC CANCER MODELS IN FISH

摘要

The present invention provides transgenic fish whose genome has stably- integrated therein an oncogene operably linked to a promoter, Methods of making the transgenic fish and methods for their use are also provided. In o ne embodiment, the transgenic fish may advantageously be utilized in methods of screening for drugs or agents that modulate oncogene-mediated neoplastic or hyperplastic transformation, or that modulate sensitivity to chemotherapy or radiation therapy. In another embodiment, the transgenic fish may be used methods of identifying mutations that modulate oncogene-mediated neoplastic or hyperplastic transformation, or that modulate sensitivity to chemotherapy or radiation therapy.