| 发明名称 |
2-(3-AMINOARYL)AMINO-4-ARYL-THIAZOLES AND THEIR USE AS C-KIT INHIBITORS |
| 摘要 |
<p>The present invention relates to novel compounds selected from 2-(3-aminoaryl)amino-4-aryl-thiazoles of formula (I) that selectively modulate, regulate, and/or inhibit signal transductions mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective c-kit inhibitors.</p> |
| 申请公布号 |
WO2004014903(A1) |
申请公布日期 |
2004.02.19 |
| 申请号 |
WO2003IB03685 |
申请日期 |
2003.07.31 |
| 申请人 |
AB SCIENCE;CIUFOLINI, MARCO;WERMUTH, CAMILLE;GIELTHEN, BRUNO;MOUSSY, ALAIN |
发明人 |
CIUFOLINI, MARCO;WERMUTH, CAMILLE;GIELTHEN, BRUNO;MOUSSY, ALAIN |
| 分类号 |
C07D277/20;A61K8/49;A61K9/06;A61K9/08;A61K9/10;A61K9/20;A61K9/48;A61K31/426;A61K31/4439;A61K31/444;A61K31/4545;A61K31/496;A61K31/497;A61K31/5377;A61P1/00;A61P1/04;A61P3/04;A61P7/04;A61P9/00;A61P9/06;A61P11/02;A61P11/06;A61P13/12;A61P17/00;A61P17/04;A61P17/06;A61P19/02;A61P21/00;A61P25/00;A61P27/02;A61P29/00;A61P33/00;A61P35/00;A61P37/00;A61P37/02;A61P37/06;A61P37/08;A61P43/00;C07D277/38;C07D277/42;C07D277/56;C07D417/04;C07D417/14;(IPC1-7):C07D417/04;A61K31/427;A61K31/443 |
主分类号 |
C07D277/20 |
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