| 摘要 |
<p>1,184,044. Nitrofuryl-oxadiazole derivatives. E. R. SQUIBB & SONS Inc. 13 March, 1967 [14 March, 1966; 22 July, 1966], No. 11689/67. Heading C2C. Novel compounds of formula wherein n is 0, 1 or 2 and R 1 and R 2 each represent H or acyl, or R 1 and R 2 each represent H, C 1-8 alkyl, hydroxy (C 1-8 ) alkyl or acyl only one of R 1 or R 2 being H, or R 1 and R 2 together with the nitrogen atom form a saturated 6- membered heterocyclic ring which may contain O, S or a further N, are prepared either by reaction of a compound of formula HNR 1 R 2 and a compound of formula wherein X is halogen or trichloromethyl, optionally followed by acylation if both R 1 and R 2 and H, or by direct nitrution optionally with simultaneous acylation of a compound of formula Pharmaceutical compositions having antimicrobial activity and being in conventional forms for oral or topical administration comprise an above-novel compound and a carrier therefor.</p> |
