Triazaspiro[5,5]undecane derivative and pharmaceutical composition in which the derivative is comprised as an active component

摘要

TriazaspiroÄ5.5Üundecane derivatives of the formula (I), quaternary ammonium salts thereof, N-oxides thereof, non-toxic salts thereof, or pharmaceutical compositions comprising them, as active ingredients (wherein R<1> is formula (II) or formula (III); R<2> is alkyl or alkynyl etc.; R<3>, R<4> is H, (substituted) alkyl etc., or R<3> and R<4> together to form formula (IV); R<5> is H or alkyl). Therefore the compounds of the formula (I) regulate the effect of chemokine/chemokine receptor, they are used for prevention and treatment of various inflammatory diseases, asthma, atopic dermatitis, urticaria, allergic diseases, nephritis, nephropathy, hepatitis, arthritis or rheumatoid arthritis etc.