COMPOSITIONS AND METHODS INVOLVING INHIBITING OR ENHANCING THE DEUBIQUITYLATION OF AN ENZYME
摘要
<p>The human homologs of the yeast ubp8 gene and polypeptide are required for chromatin development and gene regulation of the genes in the SAGA complex, including H2B. Compounds that inhibit the expression or activity of the human Ubp8 homolog polypeptide and the nucleic acid sequences encoding it are useful in rendering a cancer cell more sensitive to additional anti-tumor therapies, in diagnosing tumorigenic cells, or in treating or diagnosing other disorders dependent upon regulation of genes requiring deubiquitylation for transcription.</p>
申请公布号
WO2004003004(A1)
申请公布日期
2004.01.08
申请号
WO2003US16238
申请日期
2003.06.27
申请人
THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY;BERGER, SHELLEY, L.;HENRY, KARL, W., JR.;MCMAHON, STEVEN, B.
发明人
BERGER, SHELLEY, L.;HENRY, KARL, W., JR.;MCMAHON, STEVEN, B.
