发明名称 |
NOVEL TRICYCLIC HYDROXY CARBOXAMIDES AND DERIVATIVES THEREOF; TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS |
摘要 |
This invention provides novel substituted tricyclic carboxamides which act as oxytocin receptor competitive antagonists, as well as methods of their manufacture, pharmaceutical compositions and methods of their use in treatment, inhibition, suppression or prevention of preterm labor, dysmenorrhea and endometritis, suppression of labor at term prior to caesarean delivery, and to facilitate antinatal transport to a medical facility. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders. |
申请公布号 |
EP1377583(A1) |
申请公布日期 |
2004.01.07 |
申请号 |
EP20020728748 |
申请日期 |
2002.04.11 |
申请人 |
WYETH |
发明人 |
FAILLI, AMEDEO, ARTURO;SHUMSKY, JAY, SCOTT;CAGGIANO, THOMAS, JOSEPH;SABATUCCI, JOSEPH, PETER;MEMOLI, KEVIN, ANTHONY;TRYBULSKI, EUGENE, JOHN;SANDERS, WILLIAM JENNINGS |
分类号 |
A61K31/5517;A61P1/16;A61P7/02;A61P9/04;A61P9/12;A61P15/00;A61P15/06;A61P15/18;A61P25/18;A61P25/22;A61P27/06;A61P27/10;A61P27/16;A61P43/00;C07D471/14;C07D487/04 |
主分类号 |
A61K31/5517 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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