发明名称 |
PRODURG, MEDICINAL UTILIZATION THEREOF AND PROCESS FOR PRODUCING THE SAME |
摘要 |
<p>A prodrug with the use of an enzyme showing different enzymatic activities between a drug target site and a site where its side effect is expressed, which has a substituent cleavable with the enzyme and is activated due by cleaving the substituent. As an example of the drug target site, a respiratory organ may be cited, while the heart may be sited as an example of the side effect expression site. As an example of the drug, a bronchodilator may be cited while a glicosidase (for example, beta-glucuronidase) may be cited as an example of the enzyme. As an example of the substituent, a glycosyl group comprising a monosaccharide or an oligosaccharide may be cited. Use of the above enzyme makes it possible to lessen the side effect of a drug having a target site for exerting its effect which is different from a site where its side effect is expressed.</p> |
申请公布号 |
WO2004000863(A1) |
申请公布日期 |
2003.12.31 |
申请号 |
WO2003JP07868 |
申请日期 |
2003.06.20 |
申请人 |
NIPPON SUISAN KAISHA, LTD.;YAMASHITA, SHINYA;TAKEO, JIRO;OKITA, TAKAAKI |
发明人 |
YAMASHITA, SHINYA;TAKEO, JIRO;OKITA, TAKAAKI |
分类号 |
A61P43/00;A61P11/00;A61P11/06;A61P11/08;C07H15/18;C07H15/203;(IPC1-7):C07H15/203;A61K31/702 |
主分类号 |
A61P43/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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