MEDICAMENT WITH DELAYED RELEASE OF THE ACTIVE SUBSTANCE, CONTAINING 1-DIMETHYLAMINO-3-(3-METHOXY-PHENYL)-2-METHYL-PENTAN-3-OL

摘要

The invention relates to a pharmaceutical formulation with delayed release o f the agent, containing 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3 - ol or one of the pharmaceutically acceptable salts thereof in a matrix. Said matrix contains 1 to 80 percent by weight of one or several hydrophilic or hydrophobic polymer/s as pharmaceutically acceptable matrix-forming substance/s and has the following dissolution rate: 3-35 percent by weight (relative to 100 percent by weight of active substance) of 1-dimethylamino-3 - (3-methoxy-phenyl)-2-methyl-pentan-3-ol are released after 0.5 hours; 5-50 percent by weight of % 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan- 3- ol are released after 1 hour; 10-75 percent by weight of 1-dimethylamino-3-( 3- methoxy-phenyl)-2-methyl-pentan-3-ol are released after 2 hours; 15-82 perce nt by weight of 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol are released after 3 hours; 30-97 percent by weight of 1-dimethylamino-3-(3- methoxy-phenyl)-2-methyl-pentan-3-ol are released after 6 hours; more than 5 0 percent by weight of 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3- ol are released after 12 hours; more than 70 percent by weight of 1-dimethylami no- 3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol are released after 18 hours; more than 80 percent by weight of 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol are released after 24 hours.