发明名称 |
Cloning and recombinant production of polistinae venom enzymes, such as phospholipase and hyaluronidase, and immunological therapies based thereon |
摘要 |
A unique clone of a Polistinae venom enzyme, recombinantly produced Polistinae venom enzymes, and methods of using the recombinant enzymes are provided. In a specific example, both phospholipase and hyaluronidase cDNA from Polistes annulares contain apparent "intronic" sequences. In still a further embodiment, genetic engineering permits the construction of the "intronic" sequences to yield a useful coding sequence for expression of mature Polistinae venom enzyme proteins.
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申请公布号 |
US6652851(B1) |
申请公布日期 |
2003.11.25 |
申请号 |
US20010806658 |
申请日期 |
2001.05.24 |
申请人 |
THE ROCKEFELLER UNIVERSITY |
发明人 |
KING TE PIAO |
分类号 |
C12N15/09;A61K38/46;A61K39/00;A61K48/00;A61P31/12;A61P31/18;A61P37/06;A61P37/08;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/16;C12N9/18;C12N9/20;C12N9/26;(IPC1-7):A61K38/46;C07H21/04 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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