ABUSE-RESISTANT OPIOID SOLID DOSAGE FORM

摘要

The present invention pertains to a solid dosage form comprising an analgesically effective amount of opioid analgesic and an opioid abuse- deterring amount of a nontoxic N-methyl-D-aspartate receptor antagonist contained in a carrier which isolates, or separates, the antagonist from the opioid analgesic. The nontoxic N-methyl-D-aspartate receptor antagonist is released and made available only when the dosage form is misused, as would b e the case when the dosage form is crushed or dissolved and thereafter administered in a manner other than that indicated, e.g., by injection or intranasally.