SODIUM SALT OF 3-(4-CINNAMYL-1-PIPERAZINYL)-IMINOMETHYL RIFAMYCIN AND METHOD FOR ITS PREPARATION

摘要

The compound is active against grammenegative and grammepositive microorganisms and tuberculous microbacteria, including rifamycin-resistant ones, and can find application in medicine. Its salt has the following formula The method consists in a reaction between equimolar quantities of 3-(4-cinnamyl-1-piperazinyl)-iminomethyl rifamicyn SV and sodium ascorbate with subsequent addition of 30% methanol solution of sodium methylate. The solvent is then filterd and separated by distillation at lower pressure. The compound can also be produced by the preparation of a sodium salt of 3-formyl rifamycin SV, which reacts with N1-amino-N4-cinnamylpiperazine in a medium of inert solvent at room temperature. 4 claims