| 摘要 |
A method for the production of recombinant peptides by fed-batch cultivation of a microorganism in a bioreactor containing a medium comprising organic carbon source, nitrogen source and mineral salts. The cultivation is carried out by the addition of the organic carbon source in oscillation feed and/or by oscillation variation of stirring speed, without exhaustion of the organic carbon source during the oscillation period, wherein the oscillation has a wave period of from about 1 to about 30 minutes. The microorganism is a biological host selected from the group consisting of bacteria, yeast and animal cell. The cultivation conditions remain aerobic.
|
