| 发明名称 |
METHOD FOR MONITORING AND MODULATING PROTEIN FOLDING |
| 摘要 |
This invention relates to a new method for improving functional protein expression whereby the folding process is monitored by online measurement and, if required, the protein folding is influenced by adding folding promoting agents and/or co-expression of the periplasmic chaperone (Skp). In this respect, the invention offers a technology to improve the yield of functionally expressed recombinant proteins. |
| 申请公布号 |
WO03004698(A3) |
申请公布日期 |
2003.10.30 |
| 申请号 |
WO2002EP07346 |
申请日期 |
2002.07.03 |
| 申请人 |
MERCK PATENT GMBH;HORN, UWE;STRITTMATTER, WOLFGANG;RIESENBERG, ULRIKE HF |
发明人 |
HORN, UWE;RIESENBERG, DIETER DI;STRITTMATTER, WOLFGANG |
| 分类号 |
C12N15/09;C12N15/85;C12P21/02;C12P21/06;C12Q1/02;C12Q1/68;G01N33/68 |
主分类号 |
C12N15/09 |
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