发明名称 |
PROCESS FOR SMALL PARTICLE FORMATION |
摘要 |
The present invention is concerned with a process for the preparation of sma ll particles through precipitation. More particularly, the present invention relates to such a process which employs a fluid solution comprising a solven t and solute to be precipitated and a non-gaseous antisolvent, said solvent being soluble in or miscible with the antisolvent and said solute being substantially insoluble in the antisolvent, wherein the process comprises th e successive steps of: a. feeding a stream of the fluid solution and a stream of the antisolvent into a mixing zone (5) where both streams are thoroughly mix ed to achieve a condition of super saturation whilst ensuring that hardly any nucleation occurs during the mixing; b. feeding the resulting mixture of the fluid solution and the antisolvent into a nucleation zone (6) allowing nucleation to commence; c. allowing the nuclei formed in the nucleation zone the grow to particles with a volume weighted average diameter of no more tha n 50 ~m, preferably of no more than 7 ~m. d. collecting the particles and separating them from the antisolvent.
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申请公布号 |
CA2482272(A1) |
申请公布日期 |
2003.10.23 |
申请号 |
CA20032482272 |
申请日期 |
2003.03.06 |
申请人 |
FEYECON DEVELOPMENT & IMPLEMENTATION B.V. |
发明人 |
WUBBOLTS, FRANK EMILE;PELLIKAAN, HUBERT CLEMENS |
分类号 |
B01J2/04;(IPC1-7):B01J2/04 |
主分类号 |
B01J2/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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