METHOD FOR THE SYNTHESIS OF UNIQUELY D-PEPTIDES AND PEPTIDE NUCLEIC ACIDS

摘要

The invention relates to a method for the synthesis of a uniquely D-polypeptide, using an enzyme, comprising the following steps: (f) preparation of an amino component, where said amino component comprises at least one D-amino acid and is preferably a uniquely D-polypeptide, (g) preparation of the carboxy component, where said carboxy component comprises a leaving group and at least one D-amino acid and is preferably a uniquely D-polypeptide and (h) reaction of the amino component and the carboxy component in the presence of the enzyme to form a peptide bond between the amino component and the carboxy component with cleavage of the leaving group to give the uniquely D-polypeptide.