发明名称 |
TNP-470 POLYMER CONJUGATES AND USE THEREOF |
摘要 |
The present invention relates to conjugates of water-soluble polymers and o~(chloracetyl-carbamoyl) fumagillol (TNP-470) and use of those conjugates a s specific intracellular carriers of the TNP-470 into tumor vessels. The prese nt invention further relates to use of those conjugates to lower the neurotoxicity of TNP-470. Preferably, the polymer has a molecular weight in the range of 100 Da to 800 kDa. More preferably, the polymer has a molecular weight no greater than 60 kDa. Most preferably, the polymer has a molecular weight in the range of 15 kDa to 40 kDa.
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申请公布号 |
CA2480666(A1) |
申请公布日期 |
2003.10.23 |
申请号 |
CA20032480666 |
申请日期 |
2003.04.10 |
申请人 |
CHILDREN'S MEDICAL CENTER CORPORATION |
发明人 |
FOLKMAN, JUDAH;SATCHI-FAINARO, RONIT |
分类号 |
A61K31/785;A61K39/395;A61K45/00;A61K47/48;A61P9/00;A61P35/00;C07D303/22;(IPC1-7):A61K47/48;A61K47/32;A61K31/336;A61K47/42 |
主分类号 |
A61K31/785 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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