COMPOSITION FOR TREATING OCULAR DISEASE, CONTAINING HUMAN INTEGRIN BINDING PROTEIN OR PEPTIDE AS EFFECTIVE COMPONENT

摘要

PURPOSE: A therapeutic agent composition for treatment of ocular disease, containing saxatilin or human integrin binding protein having a similar sequence to the same as an effective ingredient and carriers is provided. The composition is effective in treatment of ocular disease such as diabetic retinopathy, age-related macular degeneration, retinopathy of prematurity, disease associated with angiogenesis such as angiogenesis-induced glaucoma, angiogenesis-induced corneal disease, etc. CONSTITUTION: The pharmaceutical composition for treatment of ocular disease associated with angiogenesis contains: saxatilin or human integrin binding protein having a similar sequence to the same; and furthermore carriers for suitable transmitting the drug. The carriers contain polyethylene glycol, dextran and a surfactant as a main component. The effective amount of the composition is in the range of 1microgram to 10mg per kg body weight in the case of vascular injection, 1ng to 1mg per eyeball in the case of ocular injection, and 1ng to 1mg per 1ml eye drop in the case of an eye drop.