New double-stranded oligonucleotides, useful e.g. for treatment and diagnosis of tumors, comprise complementary strands with single-stranded overhangs

摘要

Double-stranded oligonucleotides (I) consisting of two complementary strands (Ia; Ib), each having at one of their 3' and 5' ends 1-5 unpaired nucleotides, forming single-stranded overhangs, are new. One of (Ia) and (Ib) is complementary to a target sequence, of DNA or RNA, that is to be specifically repressed.